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Lymphoid-tyrosine-phosphatase which is encoded by the protein tyrosine phosphatase non-receptor 22 ( ) gene plays a pivotal role in the regulation of immune responses by dephosphorylating several signaling intermediates of immune cells. Since a balanced immune response has been shown to be important during pregnancy, the purpose of this research was to compare the frequency of the C1858T polymorphism in women with unexplained recurrent pregnancy loss (URPL) vs. in a control group for the first time. Genomic DNA from 200 individuals with
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