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BACKGROUND This article highlights the contributions made by historically Black colleges and universities (HBCUs) to the nursing profession, as well as the challenges faced by HBCUs as they make these important contributions. METHOD This study uses a mixed-methods approach that includes historical, qualitative, and quantitative methods. RESULTS This study includes an overview of the history of the contributions of HBCUs to nursing, how HBCU nursing programs collaborate with majority institutions, strategies for retaining and supporting African Ameri