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Although gender differences in protected responses have already been reported, the results of the difference in metabolic environment on VAT-Treg are not clear. We investigated the localization of VAT-Treg in female mice when comparing to that in male mice. On a high-fat diet (HFD), VAT-Treg decreased in male mice but increased in female mice. The rise was abolished in ovariectomized and HFD-fed mice, but was restored by estrogen supplementation. The IL33 receptor
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