https://ex229activator.com/a-t....hought-for-your-surg
The natural basic products combretastatin A-1 (CA1) and combretastatin A-4 (CA4) function as potent inhibitors of tubulin polymerization and as discerning vascular disrupting agents (VDAs) in tumors. Bioreductively activatable prodrug conjugates (BAPCs) can boost selectivity by offering as substrates for reductase enzymes particularly in hypoxic areas of tumors. A number of CA1-BAPCs incorporating nor-methyl, mono-methyl, and gem-dimethyl nitrothiophene triggers were synthesized as well as corresp
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