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The introduction of MUP in Scotland was associated with a 3.5% [95% confidence interval (CI)=2.2-4.9%] reduction in off-trade alcohol sales per adult after adjustment for the best available geographical control, disposable income and substitution. In unadjusted analysis, the introduction of MUP was associated with a 2.0% (95% CI=0.4-3.6%) reduction in off-trade alcohol sales per adult in Scotland. In EW, there was a 2.4% (95% CI=0.8-4.0%) increase during the same time-period. The reduction in off-trade alcohol sales in Scotland was driv