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Papillary thyroid carcinoma (PTC) is the most common type of thyroid carcinoma. To investigate the clinical significance of programmed death ligand 1 (PD-L1) and phosphoinositide-dependent protein kinase 1 (PDK1) in PTC. A total of 194 PTC patients were recruited. Contralateral normal thyroid tissues were obtained and used as controls (n = 8. The expression levels of PD-L1, PDK1 and p-Akt were determined using immunohistochemistry. The PD-L1, PDK1 and p-Akt were upregulated in cancer tissues compared to the normal tissues. The mean opti