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Human vitamin E (α-tocopherol) catabolism is a mechanism for regulating whole-body α-tocopherol. To determine the roles of the intestine and liver on α-tocopherol catabolism as affected by fat or fasting, 2 deuterium-labeled (intravenous d6- and oral d3-) forms of α-tocopherol were used. Healthy women received intravenous d6-α-tocopherol and consumed d3-α-tocopherol with a 600-kcal defined liquid meal (DLM; 40% or 0% fat, n=1 followed by controlled meals; or the 0% fat DLM (n=7) followed by a 12-h fast (0% fat-fast), then controlled me
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