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Metabolic shifting between glycolysis and mitochondrial oxidative phosphorylation is implicated in macrophage polarization. M1 macrophages primarily depend on glycolysis, whereas M2 macrophages rely on the tricarboxylic acid cycle and oxidative phosphorylation; therefore, facets that affect macrophage metabolism may disrupt M1/M2 homeostasis and exacerbate irritation. The mechanisms in which obesity and high blood pressure may synergistically induce macrophage metabolic disorder, particularly during