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In this issue, Smyth and colleagues investigate the natural history of AKT1-mutant metastatic breast cancer using the AACR Project GENIE, a novel research platform comprised of real-world, clinicogenomic data. A rare subset of tumors, AKT1-mutant breast cancers demonstrated similar clinical and demographic characteristics and overall survival as AKT1-wild-type tumors, but a longer duration of therapy on mTOR inhibitors.See related article by Smyth et al., p. 526. ©2020 American Association for Cancer Research.BACKGROUND Given uncertaint
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