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Older adults with acute myeloid leukemia (AML) often have significant comorbidities. We hypothesized that greater comorbidity burden predicts worse 1-month mortality and overall survival (OS) in patients≥60 years with AML. We included 50,668 patients≥60 years diagnosed between 2004 and 2014 from the National Cancer Database; patients were divided into 3 groups with Charlson comorbidity index (CCI) 0, 1, and≥2. Chi-square tests were used to examine the association between CCI and different variables. We used logistic regression and Cox