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he thickness of the retina and total macular volume. The lack of improvements of visual acuity is most likely associated with a small amount of IVI.There are currently no reliable biomarkers for predicting the response to treatment of diabetic macula edema (DME). To asses the predictive role of neurodegenerative biomarker of the response to anti-VEGF therapy of DME. Examination and treatment was carried out on 14 patients (20 eyes) with DME. The eyes were divided into 2 groups by the type of diabetes 6 eyes with type 1 diabetes and 14 eye