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© The Association for Clinical and Translational Science 2019.Navigating the investigation domain at an academic medical center are challenging, even for experienced detectives. To handle this, Duke University established two projects (1) an investigation navigation "hotline" to present brief help with a number of research concerns; and (2) researcher onboarding and consultation, a one-to-one tailored offering to ensure that researchers are prepared to navigate study resources and operations efficiently.