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The mRNA relative transcription levels of ERα, progesterone receptor (PgR), DNA methyltransferase1 (Dnmt1), DNA methyltransferase3A (Dnmt3A), and DNA methyltransferase3B (Dnmt3 were detected by real-time quantitative PCR (RT-qPCR). The ovary of female offspring with PND 56 was treated with bisulfite sequence PCR (BSP). Our results showed that, compared with the BPA group, 40 mg/kg CCFs significantly reduced the ovarian index of F1 females and the ovarian cytoapoptosis (P less then 0.01). CCFs also can alleviate the injure of the level