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Overall, we confirm that Pb exposure during adolescence promotes autophagic processes in the aged mice brain and that autophagic degradation is hindered, ultimately leading to a failure of autophagic degradation. To assess preretinal abnormal tissue (PAT) using en face OCT in eyes with idiopathic macular holes (MHs). Retrospective, observational study. Patients with MH who received 6× 6-mm spectral-domain-OCT scans. Preretinal abnormal tissue was detected by en face OCT images with a custom slab, defined with an anterior bound