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Significant differences were found in the experimental group following intervention (p0.001), and when comparing baseline and follow-up assessments (p0.05) in all variables. The frequency of hemarthrosis (p=0.04) and functionality (p=0.01) improved in patients who received manual therapy as compared to the control group. Fascial therapy achieves improvements in terms of frequency of hemarthrosis in patients with hemophilic ankle arthropathy. Ankle functionality improved in patients treated with manual therapy. This technique can im