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This study estimated the seroprevalence and risk factors of Chagas disease (CD) in a population of the Quixeré municipality, Ceará. We conducted serological methods to detect the Trypanosoma cruzi infection. The other variables were evaluated by a standardized questionnaire. The estimated prevalence of CD was 3.7%. Male sex, age 40 years, being farmers, low education level, origin from rural areas, and being born in Quixeré were significantly associated with infection. CD persists in this rural population of Northe