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How Does ADHD Medication Work? When a neuron transmits an electrical signal to another, it makes use of neurotransmitters or chemicals. They need to travel through a tiny gap known as the synapse. Some ADHD medications make the transmission of these messages more efficient. They either help neurons release neurotransmitters faster or slow the process of reuptake (called reuptake inhibitors). Doctors place patients with ADHD with a small dose of medication and observe their responses. They alter the dos