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36 ± 0.09 cm2 to 0.29 ± 0.09 cm2, P 0.001), vena contracta (VC) (P 0.001), the regurgitant volume (RV) (P 0.001), and systolic pulmonary artery pressure (sPAP) (P 0.001). This is the first study to investigate the relationship of changes in severity of MR with volume-load by monitoring the proBNP levels among patients with HF. The present results demonstrated that volume reduction, as evidenced by a decline in the proBNP levels, was accompanied by a marked reduction in the EROA, VC, and the RV among patients with left