https://www.selleckchem.com/pr....oducts/gsk2879552-2h
We found that BPA bound directly to the IP3 binding core domain of the IP3 receptor, and BPA competed with IP3 on this site. In addition, overexpression of this domain of the IP3 receptor in Hep3B cells inhibited the stabilization of Nrf2 by BPA. These results clarified that the IP3 receptor is a new target of BPA, and that BPA induces Ca2+ efflux from the endoplasmic reticulum via activation of the IP3 receptor.The creation of an arteriovenous fistula instead of a synthetic vascular graft is a smart decision in hemodialysis pat
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