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Ras-related dexamethasone-induced 1 ( ) is abnormally expressed in many solid cancers. However, its potential role in adults with B-cell acute lymphoblastic leukemia (B-ALL) is unclear. Therefore, we aim to clarify the abnormal expression of the tumor-associated biomarker, , as a potential target for diagnosis and prognosis in adult Philadelphia-negative B-ALL. The expression of was detected with RT-qPCR in 92 adults with de novo Ph-negative B-ALL and 40 healthy controls. The correlation between transcript levels and relapse was assessed.