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© 2020, García-González et al.eLife is making changes to its policies on peer review in response to the impact of COVID-19 on the scientific community. © 2020, Eisen et al.Protein ubiquitination is a very diverse post-translational modification leading to protein degradation or delocalization, or altering protein activity. In Arabidopsis thaliana, two E3 ligases, BIG BROTHER (B and DA2, activate the latent peptidases DA1, DAR1 and DAR2 by mono-ubiquitination at multiple sites. Subsequently, these activated peptidases destabilize vari
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