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The effect of localised head and neck per-cooling on central and peripheral fatigue during high thermal strain was investigated. Fourteen participants cycled for 60 min at 50% V̇O2peak on three occasions CON (18°C), HOT (35°C) and HOT with cooling (HOTcooling). Maximal voluntary force (MVF) and central activation ratio (CAR) of the knee extensors were measured every 30s during a sustained maximal voluntary contraction (MVC). Triplet peak force was measured following cycling, pre-and post the MVC. Rectal temperatures were higher in HOTcooling (39.2 ± 0.6°C)