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Tom70 serves as a docking site for cytosolic chaperone proteins and co-chaperones and is therefore active in the uptake of recently synthesized chaperone-bound proteins in mitochondrial biogenesis. In yeast, Tom70 also mediates ER-mitochondria associates via binding to sterol transporter Lam6/Ltc1. In mammalian cells, TOM70 promotes endoplasmic reticulum (ER) to mitochondria Ca2+ transfer by organization utilizing the inositol-1,4,5-triphosphate receptor kind 3