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Mean comorbidity number was 2.2 (± 1.34). Patients with 4+ comorbidities had higher rates of 30-day all-cause death/HF hospitalization as compared with patients with no comorbidities [odds ratio (OR) 3.32, 95% confidence interval (CI) 1.61-6.84; P less then 0.01]. Similar results were seen with respect to 180-day death (OR 2.13, 95% CI 1.33-3.43; P less then 0.01). Higher comorbidity burden was associated with higher 180-day costs of care and length of stay. CONCLUSIONS Higher comorbidity burden is associated with poor clinical out