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Additionally, a nematode (Caenorhabditis elegans) model, previously used for investigating the mechanisms of processes such as aging, neurodegeneration, oxidative stress and inflammation, is presented as an emerging approach for the study of polyphenols interacting gut microbiota. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.Controlling adverse events through dose reduction can enhance drug adherence and treatment response. Currently, there is no guide for sora