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41 [95% CI, 1.23-1.62], =6.0×10 , VWF odds ratio, 1.28 [95% CI, 1.07-1.52], =0.0073). In single variant sensitivity analysis, the locus was the strongest genetic instrument for both FVIII and VWF. Our results suggest a role for hemostasis, and by extension, thrombosis in PAD. Further study is warranted to determine whether VWF and FVIII independently affect the biology of PAD. Our results suggest a role for hemostasis, and by extension, thrombosis in PAD. Further study is warranted to determine whether VWF and FVIII independently affec
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