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The intensity of expression in dysplastic and malignant tissues was significantly reduced compared with normal tissues ( =0.0001). The expression of galectin-8 did not correlate with stage ( =0.303), lymph node involvement ( =0.326), tumor grade ( =0.769), distant metastasis ( =0.748), and age ( =0.574). We observed that the expression of galectin-8 in dysplastic and malignant squamous epithelium significantly reduced compared with the normal counterpart of them in the head and neck. It may contribute to malignant transformation of hea