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Within the context of data from a previously published model our work suggests that gene expression profiles associated with hypoxia, stemness and drug resistance may reside in tumor subpopulations predictably growing in PDX models. This approach provides a novel opportunity for prospective mechanistic studies of ITH.Under the hypothesis that organically managed cacao agroforestry systems report a lower global warming potential (GWP) and reduce other environmental pressure indicators compared with conventionally managed systems and mono
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