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RSD impaired spatial memory and injection of multi-epitope derived from HIV-1 reversed this effect. RSD decreased IL-4, IgG1, and IgG2a levels, while multi-epitope derived from HIV-1 reversed these effects. Multi-epitope derived from HIV-1 also increased lymphocyte proliferation and decreased IL-17 levels in both control and RSD mice. Multi-epitope derived from HIV-1 may improve memory performance via induction of anti-inflammatory immune response. Multi-epitope derived from HIV-1 may improve memory performance via induction of anti-infl