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Xylazine is a nonnarcotic sedative employed for analgesia and muscle tissue relaxation exclusively in veterinary medicine. Its chemical construction is similar to clonidine and acts as a central α-2 agonist that may trigger bradycardia and transient hypertension followed closely by hypotension. We report the recognition of xylazine in 42 deaths in Connecticut from March to August 2019. Xylazine coupled with an opioid or stimulant may impact the