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ion; further research to evaluate its influence on tissue regeneration is necessary due to low methodological quality of the animal studies. High-quality in vitro evidence suggests that EDTA-treated dentine positively influences TGF-β release, cell migration, attachment and differentiation; further research to evaluate its influence on tissue regeneration is necessary due to low methodological quality of the animal studies.Fluent conversation requires temporal organization between conversational exchanges. By performing a systematic review