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24 × 10-6 and 28.3 × 10-6. The ELCR values were observed between the acceptable limit 10-6-10-4 given by regulatory agency USEPA United States Environmental Protection Agency (1989). To investigate the changes in semen quality and bioavailable testosterone concentrations in acromegalic male patients according to their disease activity and compare them with patients with non-functional pituitary adenoma (NFA) and healthy controls (HC). Twenty-four acromegalic patients with active disease, 22 acromegalic patients in remission, 10 HCs, and 10 patient