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How Does ADHD Medication Work? The medications can reduce ADHD symptoms by increasing levels of the chemicals noradrenaline and dopamine that pass messages between brain cells. The most frequently prescribed stimulants are methylphenidate and Atomoxetine. Finding the right dose and dosage can be a trial-and error process. Communication with your doctor must be open and honest. Stimulants The stimulant drugs prescribed to treat ADHD increase levels of dopamine and the nar