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In addition, orf8 had been discovered very immunogenic in COVID-19 customers, whom showed early seropositivity for anti-orf8 IgM, IgG, and IgA. We hypothesize that orf8 secretion during SARS-CoV-2 infection facilitates early installation of B cell reaction. The serological test detecting anti-orf8 IgG antibody can be utilized for the very early and precise diagnosis of COVID-19.IMPORTANCE Current commercially readily available serological examinations for COVID-19 customers are detecting antibodies a
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