https://sirtuin-signal.com/ind....ex.php/icariin-impro
In this study, we found that overexpression of miR-17-5p led to less apoptosis and lower drug susceptibility in vitro and in vivo beneath the 5-fluorouracil (5-FU) treatment, which suggested miR-17-5p led to 5-FU chemotherapy resistance. Bioinformatic analysis suggested that miR-17-5p-mediated chemoresistance ended up being connected with mitochondrial homeostasis. miR-17-5p directly bound into the 3' untranslated region of Mitofusin 2 (MFN2), leading to reduced mitochondrial
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