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40, 95% confidence interval [CI] 1.43-49.41, P=.0186). Multivariable analysis of the PHIS dataset identified CVC placement (OR 1.97, 95% CI 1.57-2.46; P.0001), obesity (OR 2.96, 95% CI 1.21-7.26; P=.0177), andmore than one hospital admission (OR 3.54, 95% CI 2.69-4.64; P.0001) as significant predictors of VTE. VTE diagnosis was not associated with increased mortality in either cohort. The VTE rate in children with CNS tumors is low (2%). CVC placement was identified as a modifiable risk factor in both cohorts. The VTE rate in chil
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