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Mexican mothers have an important role in adolescent sexuality; however, they report multiple barriers to parent-child sex communication, which may impact adolescent sexual behaviour. This cross-sectional study examines whether adolescent perceptions of maternal barriers to communication are associated with adolescent sexual behaviour frequency indirectly through its association with maternal monitoring, and whether these associations differ by age and gender. Mexican adolescents (N = 1433), ages 12-19 (53% girls), completed a survey on