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Elevated levels of plasma alpha1-antitrypsin (AAT) correlate with a poor prognosis of various cancers. Herein, we investigated effects of exogenous AAT on non-small lung cancer cell lines with high (H1975) and very low (H661) baseline expression of SERPINA1 gene encoding AAT protein. Comparison of cells grown for 3 weeks in a regular medium versus medium supplemented with 2 mg/ml of AAT revealed that in the presence of AAT cells acquire better proliferative properties, resistance to staurosporine (STS)-induced apoptosis, and show higher expression of CLU, a

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A door made of upvc that has a cat flap can help to reduce draughts in your home. By keeping your pets inside and keeping cold air out, you can save money on heating bills. While it is possible to install a cat flap in double glazing as well as upvc sealed units, it is more difficult than installing doors made of wood. This is due to different thicknesses of Upvc. Benefits A cat flap installed on your door allows you to keep your pet ins