https://www.selleckchem.com/pr....oducts/lomerizine-hc
2DG sensitization crizotinib might be associated with the inhibition of HK2-mediated glycolysis and P-ALK/AKT/mTOR signaling pathway in H3122 and H2228 cells. These results indicate that HK2-mediated glycolysis plays a crucial role in the increased tolerance of ALK NSCLC cells to crizotinib. 2DG may sensitize ALK NSCLC to crizotinib via suppression of HK2-mediated glycolysis and the AKT/mTOR signaling pathway. These results indicate that HK2-mediated glycolysis plays a crucial role in the increased tolerance of ALK+ NSCLC cells t
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