https://www.selleckchem.com/pr....oducts/epz005687.htm
PURPOSE GDC-0084 is an oral, brain-penetrant small molecule inhibitor of phosphoinositide 3-kinase (PI3K) and mammalian target of rapamycin (mTOR). Since these two targets alter tumor vascularity and metabolism, respectively, we hypothesized multi-parametric MR-PET could be used to quantify the response, estimate pharmacokinetic (PK) parameters, and predict progression-free survival (PFS) in patients with recurrent malignant gliomas. EXPERIMENTAL DESIGN Multiparametric advanced MR-PET imaging was performed to evaluate physiological re
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