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I am very pleased to welcome readers to the tenth volume of the Journal of Comparative Effectiveness Research (JCER). As in previous years, it is great to start off this issue with a look back on some of our article highlights from 2020, alongside some of this month's key content.Rezafungin is a novel echinocandin with exceptional stability and solubility and a uniquely long half-life allowing for front-loaded drug exposure with once-weekly dosing. Rezafungin has been shown comparable to other echinocandins, with activity agai