https://www.selleckchem.com/pr....oducts/Sodium-orthov
Mice displayed a seven-fold range in MTX exposure and revealed a significant exposure-response relationship (p = 0.0027). KO mice receiving the 2 mg/kg dosing regimen had 2.3-fold greater exposure to MTX (p less then 0.0001) and a 66% reduction in overall disease progression (p = 0.011) compared to WT mice. However, exposure and response were equivalent when pharmacogenetically guided dosing was used. These studies demonstrate that an exposure-response relationship exists for MTX and that Slco1b2 genotype affects MTX exposu
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