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s in b value, but no significant differences were observed between all renal tumors and the normal renal cortex. A linear correlation was found between α values and NIC in CP (r=0.780, P=0.0 and NP (r=0.693, P=0.0. The b values and NIC had a low correlation in CP, with no correlation in NP. Quantitative spectral CT with the stretched-exponential nonlinear regression analysis model may enhance the differential diagnosis ability for renal tumors. Its clinical value remains to be further explored in other types of soft tissue lesions.