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Untreated ADHD in Adults Can Lead to Feelings of Worthlessness and Depression People who suffer from untreated ADHD frequently suffer from chronic underachievement, which can cause feelings of worthlessness and depression. This is especially the case when they fail to meet their professional and personal goals. The overlapping symptoms of comorbid ADHD and depression can make it challenging to determine a precise diagnosis. However, identifying the symptoms is the first step towards getting treatment