https://www.selleckchem.com/pr....oducts/gsk-3008348-h
The potency of GK (IC5 was determined using JNK1 Kinase Enzyme System. Results We revealed that GK could ameliorate EAE disease progression by the inhibition of the Th17 cells. Further mechanism studies demonstrated that the level of phospho JNK was decreased and the level of Eomes in CD4+T cells was dramatically increased. This therapeutic effect of GK was almost completely interrupted in CD4-Eomes conditional knockout mice. Conclusions These results provided the therapeutic potential of GK treatment in EAE, and fur
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