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e., deficits across all domains). A dose-response relationship between baseline level of impairment and subsequent risk of progression to dementia was evident for aMCI profiles after controlling for age, sex, and education. Machine learning more easily classified participants with aMCI in comparison to SCD (8% vs. 21% misclassified). Cognitive performance follows distinct patterns, especially within aMCI. The patterns map onto risk of progression to dementia. Cognitive performance follows distinct patterns, especially within aMCI. The