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ADHD Stimulant Medication Stimulants improve symptoms like inattention and hyperactivity The effects are usually felt within 30 to 60 minutes. They are the first-line medication for people with ADHD. alter the activity of neurotransmitters like dopamine and noradrenaline within the tiny spaces between neurons called synapses. They also aid connected neurons to communicate better with one another. Methamphetamine Methamphetamine (also called meth, cr