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Rare variants in GRIN genes, which encode NMDAR subunits, are strongly associated with neurodevelopmental disorders. Among these, GRIN2A, which encodes the GluN2A subunit of NMDARs, is widely accepted as an epilepsy-causative gene. Here, we functionally characterize the de novo GluN2A-S1459G mutation identified in an epilepsy patient. We show that S1459 is a CaMKIIα phosphorylation site, and that endogenous phosphorylation is regulated during development and in response to synaptic activity in a dark rearing model. GluN2A-S1459 phosphoryl

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How to Choose the Best Electric Folding Bikes Foldable electric bicycles are a great alternative for city commuters. These bikes are smaller in dimensions and can be transported in an apartment or car without a bike rack. These bikes are also great for those who have limited storage space. These bikes have a pedal-assist motor that dispenses power in proportion to the amount of effort you put into cycling. Portability In contrast to conventional e-bikes, folding bikes feature an element that allows them to collapse into smaller sizes when they are th