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Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease affecting upper and lower motor neurons. We generated patient-derived-induced Pluripotent Stem Cells (iPSCs), from an ALS patient affected by an early-onset and aggressive form of the disease, carrying a missense pathogenic variant in FUS gene. We reprogrammed somatic cells using an established Sendai virus protocol and we obtained clones of iPSC. We confirmed their stemness and further generated embryoid bodies, showing their potential of differentiating in

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The aim of this research would be to report the problem prices straight linked to the surgical technique of a V-shaped TTO, where tubercle is completely released from the periosteum using a step-cut osteotomy. METHODS The retrospective case series comprised a large cohort of 263 knees with patella alta in 203 patients which underwent a V-shaped TTO, with or without additional realignment treatments, between March 2004 and October 2017. Information had been obtained from readil