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Does ADHD Medication Work? When a person is prescribed ADHD medication, they are concerned about how long the medication will last and if it works. Here are some easy answers. The stimulants alter the levels of brain chemicals that transmit messages regarding attention and activity. , norepinephrine, and other brain chemicals are included. They are the first line of treatment for adults with ADHD. 1. Stimulants Stimulants are the most commonly used medications to manage ADHD. They alter the activity of